Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas.

ABSTRACT:

Purpose

The genetic differences between human papilloma virus (HPV)-positive and -negative head and neck squamous cell carcinomas (HNSCC) remain largely unknown. To identify differential biology and novel therapeutic targets for both entities, we determined mutations and copy-number aberrations in a large cohort of locoregionally advanced HNSCC.

Experimental design

We performed massively parallel sequencing of 617 cancer-associated genes in 120 matched tumor/normal samples (42.5% HPV-positive). Mutations and copy-number aberrations were determined and results validated with a secondary method.

Results

The overall mutational burden in HPV-negative and HPV-positive HNSCC was similar with an average of 15.2 versus 14.4 somatic exonic mutations in the targeted cancer-asso

SUBMITTER: Seiwert TY 

PROVIDER: S-EPMC4305034 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature