MicroRNA 302a is a novel modulator of cholesterol homeostasis and atherosclerosis.

ABSTRACT:

Objective

Macrophage foam cell formation is a key feature of atherosclerosis. Recent studies have shown that specific microRNAs (miRs) are regulated in modified low-density lipoprotein-treated macrophages, which can affect the cellular cholesterol homeostasis. Undertaking a genome-wide screen of miRs regulated in primary macrophages by modified low-density lipoprotein, miR-302a emerged as a potential candidate that may play a key role in macrophage cholesterol homeostasis.

Approach and results

The objective of this study was to assess the involvement of miR-302a in macrophage lipid homeostasis and if it can influence circulating lipid levels and atherosclerotic development when it is inhibited in a murine atherosclerosis model. We found that transfection of primary macrophag

SUBMITTER: Meiler S 

PROVIDER: S-EPMC4305040 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature