A naturally occurring single amino acid replacement in multiple gene regulator of group A Streptococcus significantly increases virulence.

ABSTRACT: Single-nucleotide polymorphisms (SNPs) are the most common source of genetic variation within a species; however, few investigations demonstrate how naturally occurring SNPs may increase strain virulence. We recently used group A Streptococcus as a model pathogen to study bacteria strain genotype-patient disease phenotype relationships. Whole-genome sequencing of approximately 800 serotype M59 group A Streptococcus strains, recovered during an outbreak of severe invasive infections across North America, identified a disproportionate number of SNPs in the gene encoding multiple gene regulator of group A Streptococcus (mga). Herein, we report results of studies designed to test the hypothesis that the most commonly occurring SNP, encoding a replacement of arginine for histidine at codon 201

SUBMITTER: Sanson M 

PROVIDER: S-EPMC4305177 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature