Novel heteroaryl phosphonicdiamides PTPs inhibitors as anti-hyperglycemic agents.

ABSTRACT:

Background

Chronic and oral administration of benzylamine improves glucose tolerance. Picolylamine is a selective functional antagonist of the human adenosine A2B receptor. Phosphonic diamide derivatives enhance the cellular permeability and in turn their biological activities.

Methods

A series of heteroaryl phosphonicdiamide derivatives were designed as therapeutics to control and manage type2 diabetes. Initially defined Lipinski parameters encouraged them as safer drugs. Molecular docking of these compounds against Protein tyrosine phosphatase (PTP), the potential therapeutic target of type 2 diabetes, revealed their potential binding ability explaining their anti-diabetic activity in terms of PTP inhibition. Human intestinal absorption, Caco-2 cell permeability, MDCK cell

SUBMITTER: Sekhar KC 

PROVIDER: S-EPMC4305230 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature