Risk-taking in disorders of natural and drug rewards: neural correlates and effects of probability, valence, and magnitude.

ABSTRACT: Pathological behaviors toward drugs and food rewards have underlying commonalities. Risk-taking has a fourfold pattern varying as a function of probability and valence leading to the nonlinearity of probability weighting with overweighting of small probabilities and underweighting of large probabilities. Here we assess these influences on risk-taking in patients with pathological behaviors toward drug and food rewards and examine structural neural correlates of nonlinearity of probability weighting in healthy volunteers. In the anticipation of rewards, subjects with binge eating disorder show greater risk-taking, similar to substance-use disorders. Methamphetamine-dependent subjects had greater nonlinearity of probability weighting along with impaired subjective discrimination of probabili

SUBMITTER: Voon V 

PROVIDER: S-EPMC4305336 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature