Analysis of viral testing in nonacetaminophen pediatric acute liver failure.

ABSTRACT:

Objective

Viral infections are often suspected to cause pediatric acute liver failure (PALF), but large-scale studies have not been performed. We analyzed the results of viral testing among nonacetaminophen PALF study participants.

Methods

Participants were enrolled in the PALF registry. Diagnostic evaluation and final diagnosis were determined by the site investigator and methods for viral testing by local standard of care. Viruses were classified as either causative viruses (CVs) or associated viruses (AVs). Supplemental testing for CV was performed if not done clinically and serum was available. Final diagnoses included "viral," "indeterminate," and "other."

Results

Of 860 participants, 820 had at least 1 test result for a CV or AV. A positive viral test was found

SUBMITTER: Schwarz KB 

PROVIDER: S-EPMC4305349 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature