Transcriptome Analysis of the Human Striatum in Tourette Syndrome.

ABSTRACT:

Background

Genome-wide association studies have not revealed any risk-conferring common genetic variants in Tourette syndrome (TS), requiring the adoption of alternative approaches to investigate the pathophysiology of this disorder.

Methods

We obtained the basal ganglia transcriptome by RNA sequencing in the caudate and putamen of nine TS and nine matched normal control subjects.

Results

We found 309 downregulated and 822 upregulated genes in the caudate and putamen (striatum) of TS individuals. Using data-driven gene network analysis, we identified 17 gene coexpression modules associated with TS. The top-scoring downregulated module in TS was enriched in striatal interneuron transcripts, which was confirmed by decreased numbers of cholinergic and gamma-aminobutyric

SUBMITTER: Lennington JB 

PROVIDER: S-EPMC4305353 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature