Variation in the BDNF gene interacts with age to predict mortality in a prospective, longitudinal cohort with severe TBI.

ABSTRACT:

Background

Mortality predictions following traumatic brain injury (TBI), and our understanding of TBI pathology, may be improved by including genetic risk in addition to traditional prognostic variables. One promising target is the gene coding for brain-derived neurotrophic factor (BDNF), a ubiquitous neurotrophin important for neuronal survival and neurogenesis.

Objective

We hypothesized the addition of BDNF genetic variation would improve mortality prediction models and that BDNF Met-carriers (rs6265) and C-carriers (rs7124442) would have the highest mortality rates post-TBI.

Methods

This study examined BDNF functional single nucleotide polymorphisms rs6265 (val66met) and rs7124442 (T>C) in relation to mortality in a prospective, longitudinal cohort with severe TBI.

SUBMITTER: Failla MD 

PROVIDER: S-EPMC4305354 | biostudies-literature | 2015 Mar-Apr

REPOSITORIES: biostudies-literature