Minimal within-host dengue models highlight the specific roles of the immune response in primary and secondary dengue infections.

ABSTRACT: In recent years, the within-host viral dynamics of dengue infections have been increasingly characterized, and the relationship between aspects of these dynamics and the manifestation of severe disease has been increasingly probed. Despite this progress, there are few mathematical models of within-host dengue dynamics, and the ones that exist focus primarily on the general role of immune cells in the clearance of infected cells, while neglecting other components of the immune response in limiting viraemia. Here, by considering a suite of mathematical within-host dengue models of increasing complexity, we aim to isolate the critical components of the innate and the adaptive immune response that suffice in the reproduction of several well-characterized features of primary and secondary dengu

SUBMITTER: Ben-Shachar R 

PROVIDER: S-EPMC4305404 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature