Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes.

ABSTRACT: Environmental exposure to electromagnetic fields is potentially carcinogenic. The radical pair mechanism is considered the most feasible mechanism of interaction between weak magnetic fields encountered in our environment and biochemical systems. Radicals are abundant in biology, both as free radicals and reaction intermediates in enzyme mechanisms. The catalytic cycles of some flavin-dependent enzymes are either known or potentially involve radical pairs. Here, we have investigated the magnetic field sensitivity of a number of flavoenzymes with important cellular roles. We also investigated the magnetic field sensitivity of a model system involving stepwise reduction of a flavin analogue by a nicotinamide analogue-a reaction known to proceed via a radical pair. Under the experimental cond

SUBMITTER: Messiha HL 

PROVIDER: S-EPMC4305418 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature