Serum bicarbonate and bone mineral density in US adults.

ABSTRACT:

Background

Chronic metabolic acidosis leads to bone mineral loss and results in lower bone mineral density (BMD), which is a risk factor for osteoporosis-related fractures. The effect of low-level metabolic acidosis on bone density in the general population is unknown.

Study design

Cross-sectional study.

Setting & participants

9,724 nationally representative adults 20 years or older in NHANES (National Health and Nutrition Examination Survey) 1999-2004.

Factor

Serum bicarbonate level.

Outcomes

Lumbar and total BMD, as well as low lumbar and total bone mass, defined as 1.0 SD below the sex-specific mean value of young adults.

Measurements

BMD was measured by dual-energy x-ray absorptiometry and serum bicarbonate was measured in all participants.

SUBMITTER: Chen W 

PROVIDER: S-EPMC4305466 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature