The renal dopaminergic system: novel diagnostic and therapeutic approaches in hypertension and kidney disease.

ABSTRACT: Salt sensitivity of blood pressure, whether in hypertensive or normotensive subjects, is associated with increased cardiovascular risk and overall mortality. Salt sensitivity can be treated by reducing NaCl consumption. However, decreasing salt intake in some may actually increase cardiovascular risk, including an increase in blood pressure, that is, inverse salt sensitivity. Several genes have been associated with salt sensitivity and inverse salt sensitivity. Some of these genes encode proteins expressed in the kidney that are needed to excrete a sodium load, for example, dopamine receptors and their regulators, G protein-coupled receptor kinase 4 (GRK4). We review here research in this field that has provided several translational opportunities, ranging from diagnostic tests to gene the

SUBMITTER: Armando I 

PROVIDER: S-EPMC4305499 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature