Radiological correlates and clinical implications of the paradoxical lung function response to β₂ agonists: an observational study.

ABSTRACT:

Background

Bronchodilator response has been noted in a significant proportion of patients with chronic obstructive pulmonary disease (COPD). However, there are also reports of a paradoxical response to β₂ agonists resulting in bronchoconstriction. Asymptomatic bronchoconstriction is likely to be far more common than is symptomatic bronchoconstriction with β₂ agonists, but no systematic studies have been done. We assessed the prevalence of paradoxical response in current and former smokers with and without COPD, and its radiological correlates and clinical implications.

Methods

Non-Hispanic white and African-American patients (aged 45-80 years) from a large multicentre study COPDGene were classified into two groups on the basis of a paradoxical response, defined as at least a

SUBMITTER: Bhatt SP 

PROVIDER: S-EPMC4306040 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature