Exploring the utility of organo-polyoxometalate hybrids to inhibit SOX transcription factors.

ABSTRACT:

Background

SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationally engineering specific inhibitors that interfere with transcription factor DNA interfaces continues to be a monumental challenge in the field of transcription factor chemical biology. Polyoxometalates (POMs) are inorganic compounds that were previously shown to target the high-mobility group (HMG) of SOX proteins at nanomolar concentrations. In continuation of this work, we carried out an assessment of the selectivity of a panel of newly synthesized organo-polyoxometalate hybrids in targeting different transcription factor families to enable the usage of polyoxome

SUBMITTER: Narasimhan K 

PROVIDER: S-EPMC4306199 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature