Gender differences in preclinical markers of kidney injury in a rural north Carolina african-american cohort.

ABSTRACT:

Introduction

The incidence rate of end-stage renal disease (ESRD) is highest among African-American (AA) males. The reason for this disparity in ESRD for AA males remains unclear, but it is well established that diabetes is the leading risk factor. Prediabetes may also be a risk for kidney disease since prediabetics have increased risk for cardiovascular disease and often do not receive drug interventions unless their hemoglobin A1c (A1c) level is above 6%. Perhaps, AA males are at greater risk because they often are untreated prediabetics and this predisposes them to renal injury. Therefore, we hypothesize that prediabetic AA males have higher albumin:creatinine ratio (ACr), a biomarker of renal injury, than their female counterparts.

Methods

Male and female AAs were recrui

SUBMITTER: Pointer MA 

PROVIDER: S-EPMC4306298 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature