Integrative analysis of metabolic models - from structure to dynamics.

ABSTRACT: The characterization of biological systems with respect to their behavior and functionality based on versatile biochemical interactions is a major challenge. To understand these complex mechanisms at systems level modeling approaches are investigated. Different modeling formalisms allow metabolic models to be analyzed depending on the question to be solved, the biochemical knowledge and the availability of experimental data. Here, we describe a method for an integrative analysis of the structure and dynamics represented by qualitative and quantitative metabolic models. Using various formalisms, the metabolic model is analyzed from different perspectives. Determined structural and dynamic properties are visualized in the context of the metabolic model. Interaction techniques allow the explo

SUBMITTER: Hartmann A 

PROVIDER: S-EPMC4306315 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature