Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development.

ABSTRACT: Vascular development begins with formation of a primary capillary plexus that is later remodeled to give rise to the definitive vasculature. Although the mechanism by which arterial and venous fates are acquired is well understood, little is known about when during vascular development arterial and venous vessels emerge and how their growth is regulated. Previously, we have demonstrated that a hedgehog (HH)/vascular endothelial growth factor (VEGF) and angiopoeitin 2 (ANG2) signaling pathway is essential for the development of the coronary vasculature. Here, we use conditional gene targeting to identify the cell types that receive HH signaling and mediate coronary vascular development. We show that HH signaling to the cardiomyoblast is required for the development of coronary veins, while

SUBMITTER: Lavine KJ 

PROVIDER: S-EPMC4306353 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature