Association between BMP4 rs17563 polymorphism and NSCL/P risk: a meta-analysis.

ABSTRACT:

Objective

To investigate the association between bone morphogenetic protein 4 (BMP4) rs17563 polymorphism and nonsyndromic cleft lip with or without palate (NSCL/P) risk.

Methods

Four online databases were researched and the related publications were collected. Odds ratio (OR) with 95% confidence interval (CI) was applied to assess the relationship; publication bias, metaregression, and sensitivity analysis were conducted to guarantee the strength of results.

Results

Six published case-control studies were collected. Overall, no significant association between BMP4 rs17563 polymorphism and NSCL/P risk was found. It was notable that significant susceptibility on different ethnicity was observed in the stratified analysis. For Chinese population, the BMP4 rs17563 polymo

SUBMITTER: Hu YY 

PROVIDER: S-EPMC4306361 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature