The effect of bicarbonate administration via continuous venovenous hemofiltration on acid-base parameters in ventilated patients.

ABSTRACT:

Background

Acute kidney injury (AKI) and metabolic acidosis are common in the intensive care unit. The effect of bicarbonate administration on acid-base parameters is unclear in those receiving continuous venovenous hemofiltration (CVVH) and mechanical ventilatory support.

Methods

Metabolic and ventilatory parameters were prospectively examined in 19 ventilated subjects for up to 96 hours following CVVH initiation for AKI at an academic tertiary care center. Mixed linear regression modeling was performed to measure changes in pH, partial pressure of carbon dioxide (pCO2), serum bicarbonate, and base excess over time.

Results

During the 96-hour study period, pCO2 levels remained stable overall (initial pCO2 42.0±14.6 versus end-study pCO2 43.8±16.1 mmHg; P=0.13 for int

SUBMITTER: Allegretti AS 

PROVIDER: S-EPMC4306401 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature