Challenges of improving the evidence base in smaller surgical specialties, as highlighted by a systematic review of gastroschisis management.

ABSTRACT:

Objective

To identify methods of improving the evidence base in smaller surgical specialties, using a systematic review of gastroschisis management as an example.

Background

Operative primary fascial closure (OPFC), and silo placement with staged reduction and delayed closure (SR) are the most commonly used methods of gastroschisis closure. Relative merits of each are unclear.

Methods

A systematic review and meta-analysis was performed comparing outcomes following OPFC and SR in infants with simple gastroschisis. Primary outcomes of interest were mortality, length of hospitalization and time to full enteral feeding.

Results

751 unique articles were identified. Eight met the inclusion criteria. None were randomized controlled trials. 488 infants underwent OPFC a

SUBMITTER: Allin BS 

PROVIDER: S-EPMC4306505 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature