Interface of physics and biology: engineering virus-based nanoparticles for biophotonics.

ABSTRACT: Virus-based nanoparticles (VNPs) have been used for a wide range of applications, spanning basic materials science and translational medicine. Their propensity to self-assemble into precise structures that offer a three-dimensional scaffold for functionalization has led to their use as optical contrast agents and related biophotonics applications. A number of fluorescently labeled platforms have been developed and their utility in optical imaging demonstrated, yet their optical properties have not been investigated in detail. In this study, two VNPs of varying architectures were compared side-by-side to determine the impact of dye density, dye localization, conjugation chemistry, and microenvironment on the optical properties of the probes. Dyes were attached to icosahedral cowpea mosaic v

SUBMITTER: Wen AM 

PROVIDER: S-EPMC4306514 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature