Semaphorin and Eph receptor signaling guide a series of cell movements for ventral enclosure in C. elegans.

ABSTRACT:

Background

In the last stage of the Caenorhabditis elegans body wall closure, an open pocket in the epidermis is closed by the migration of marginal epidermal P/pocket cells to the ventral midline. The cellular and molecular mechanisms of this closure remain unknown.

Results

Cells within the pocket align to form a bridge for migration of contralateral P cell pair P9/10 L,R (and neighboring P cells) to the midline. Bridge formation involves rearrangement of five sister pairs of PLX-2/plexin and VAB-1/Eph receptor expressing "plexin band" cells, of which three pairs form a scaffold for bridge assembly and two pairs form the bridge. Bridge formation requires VAB-1 kinase-dependent extension of presumptive bridge cells over scaffold cells toward the ventral midline. An unassembl

SUBMITTER: Ikegami R 

PROVIDER: S-EPMC4306670 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature