Age at gluten introduction and risk of celiac disease.

ABSTRACT:

Objectives

The goal of this study was to determine whether age at introduction to gluten was associated with risk for celiac disease (CD) in genetically predisposed children.

Methods

TEDDY (The Environmental Determinants of Diabetes in the Young) is a prospective birth cohort study. Newborn infants (N = 6436) screened for high-risk HLA-genotypes for CD were followed up in Finland, Germany, Sweden, and the United States. Information about infant feeding was collected at clinical visits every third month. The first outcome was persistent positive for tissue transglutaminase autoantibodies (tTGA), the marker for CD. The second outcome was CD, defined as either a diagnosis based on intestinal biopsy results or on persistently high levels of tTGA.

Results

Swedish children

SUBMITTER: Aronsson CA 

PROVIDER: S-EPMC4306795 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature