New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis.

ABSTRACT: A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolite ikarugamycin (4). Their structural elucidation was accomplished using a combination of electrospray-time of flight mass spectrometry (ESI-TOF MS) and 1D and 2D NMR analyses. Compounds 1-3 showed antifungal activity against Aspergillus fumigatus, Candida albicans and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).

SUBMITTER: Lacret R 

PROVIDER: S-EPMC4306928 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature