Biological mechanism analysis of acute renal allograft rejection: integrated of mRNA and microRNA expression profiles.

ABSTRACT:

Objectives

Renal transplantation is the preferred method for most patients with end-stage renal disease, however, acute renal allograft rejection is still a major risk factor for recipients leading to renal injury. To improve the early diagnosis and treatment of acute rejection, study on the molecular mechanism of it is urgent.

Methods

MicroRNA (miRNA) expression profile and mRNA expression profile of acute renal allograft rejection and well-functioning allograft downloaded from ArrayExpress database were applied to identify differentially expressed (DE) miRNAs and DE mRNAs. DE miRNAs targets were predicted by combining five algorithm. By overlapping the DE mRNAs and DE miRNAs targets, common genes were obtained. Differentially co-expressed genes (DCGs) were identified by di

SUBMITTER: Huang SM 

PROVIDER: S-EPMC4307466 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature