Impact of vitamin D receptor gene polymorphisms in pathogenesis of Type-1 diabetes mellitus.

ABSTRACT:

Background

Type 1 diabetes mellitus (TIDM) results from an immune-mediated destruction of insulin-producing-cells in the pancreatic islets of Langerhans. There are clear differences in immunogenetic predisposition to type1 diabetes among countries. Studies have indicated that vitamin D supplementation in early childhood decreases the risk of TIDM. Vitamin D exerts its action via the nuclear vitamin D receptor (VDR), which shows an extensive polymorphism. VDR gene polymorphisms have been associated with altered gene expression or gene function. Four single nucleotide polymorphisms (SNPs) in the VDR gene produce variation in four recognition sites. These recognition sites variants include Fok I, Bsm I, Apa I and Taq I.

Aim of the study

TO investigate the relationship between V

SUBMITTER: Kamel MM 

PROVIDER: S-EPMC4307509 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature