Identifying tandem Ankyrin repeats in protein structures.

ABSTRACT:

Background

Tandem repetition of structural motifs in proteins is frequently observed across all forms of life. Topology of repeating unit and its frequency of occurrence are associated to a wide range of structural and functional roles in diverse proteins, and defects in repeat proteins have been associated with a number of diseases. It is thus desirable to accurately identify specific repeat type and its copy number. Weak evolutionary constraints on repeat units and insertions/deletions between them make their identification difficult at the sequence level and structure based approaches are desired. The proposed graph spectral approach is based on protein structure represented as a graph for detecting one of the most frequently observed structural repeats, Ankyrin repeat.

Resul

SUBMITTER: Chakrabarty B 

PROVIDER: S-EPMC4307672 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature