Association between CYP1B1 gene polymorphisms and risk factors and susceptibility to laryngeal cancer.

ABSTRACT:

Background

The aim of this study was to investigate the association between polymorphism of the cytochrome P450 1B1 (CYP1B1) gene, a metabolic enzyme gene, and the susceptibility to laryngeal cancer among the Chinese Han population.

Material/methods

In a case-control study, we investigated polymorphisms in the CYP1B1 gene (rs10012, rs1056827, and rs1056836) with a real-time quantitative polymerase chain reaction (PCR) assay (TaqMan). The study was conducted with 300 Chinese Han patients with laryngeal cancer and 300 healthy Chinese Han subjects in a control group. We also studied the interactions between genetic polymorphism and risk factors such as smoking and alcohol consumption in the pathogenesis of laryngeal cancer.

Results

There were statistically significant di

SUBMITTER: Yu PJ 

PROVIDER: S-EPMC4307736 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature