Designing inhibitors of anthrax toxin.

ABSTRACT:

Introduction

Present-day rational drug design approaches are based on exploiting unique features of the target biomolecules, small- or macromolecule drug candidates and physical forces that govern their interactions. The 2013 Nobel Prize in chemistry awarded 'for the development of multiscale models for complex chemical systems' once again demonstrated the importance of the tailored drug discovery that reduces the role of the trial-and-error approach to a minimum. The intentional dissemination of Bacillus anthracis spores in 2001 via the so-called anthrax letters has led to increased efforts, politically and scientifically, to develop medical countermeasures that will protect people from the threat of anthrax bioterrorism.

Areas covered

This article provides an overview of t

SUBMITTER: Nestorovich EM 

PROVIDER: S-EPMC4307821 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature