Genome-scale identification and characterization of moonlighting proteins.

ABSTRACT:

Background

Moonlighting proteins perform two or more cellular functions, which are selected based on various contexts including the cell type they are expressed, their oligomerization status, and the binding of different ligands at different sites. To understand overall landscape of their functional diversity, it is important to establish methods that can identify moonlighting proteins in a systematic fashion. Here, we have developed a computational framework to find moonlighting proteins on a genome scale and identified multiple proteomic characteristics of these proteins.

Results

First, we analyzed Gene Ontology (GO) annotations of known moonlighting proteins. We found that the GO annotations of moonlighting proteins can be clustered into multiple groups reflecting their d

SUBMITTER: Khan I 

PROVIDER: S-EPMC4307903 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature