Results of the two incidence screenings in the National Lung Screening Trial.

ABSTRACT:

Background

The National Lung Screening Trial was conducted to determine whether three annual screenings (rounds T0, T1, and T2) with low-dose helical computed tomography (CT), as compared with chest radiography, could reduce mortality from lung cancer. We present detailed findings from the first two incidence screenings (rounds T1 and T2).

Methods

We evaluated the rate of adherence of the participants to the screening protocol, the results of screening and downstream diagnostic tests, features of the lung-cancer cases, and first-line treatments, and we estimated the performance characteristics of both screening methods.

Results

At the T1 and T2 rounds, positive screening results were observed in 27.9% and 16.8% of participants in the low-dose CT group and in 6.2% and

SUBMITTER: Aberle DR 

PROVIDER: S-EPMC4307922 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature