Distinct metabolic responses of an ovarian cancer stem cell line.

ABSTRACT:

Background

Cancer metabolism is emerging as an important focus area in cancer research. However, the in vitro cell culture conditions under which much cellular metabolism research is performed differ drastically from in vivo tumor conditions, which are characterized by variations in the levels of oxygen, nutrients like glucose, and other molecules like chemotherapeutics. Moreover, it is important to know how the diverse cell types in a tumor, including cancer stem cells that are believed to be a major cause of cancer recurrence, respond to these variations. Here, in vitro environmental perturbations designed to mimic different aspects of the in vivo environment were used to characterize how an ovarian cancer cell line and its derived, isogenic cancer stem cells metabolically respon

SUBMITTER: Vermeersch KA 

PROVIDER: S-EPMC4308021 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature