Crosslinking decreases the hemocompatibility of decellularized, porcine small intestinal submucosa.

ABSTRACT: Decellularized tissues have been widely used as scaffolds for biomedical applications due to their presentation of adhesion peptide sequences and growth factors, which facilitate integration with surrounding tissue. One of the most commonly used decellularized tissues is derived from porcine small intestinal submucosa (SIS). In some applications, SIS is crosslinked to modulate the mechanical properties or degradation rate of the scaffold. Despite the widespread use of SIS, there has been no mechanistic characterization of blood reactions with SIS, or how crosslinking affects these reactions. Therefore, we characterized the effect of SIS and carbodiimide-crosslinked SIS (cSIS) on plasma coagulation, including targeted assessments of the intrinsic and extrinsic coagulation pathways, and thro

SUBMITTER: Glynn JJ 

PROVIDER: S-EPMC4308447 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature