Components of hemodynamic load and cardiovascular events: the Framingham Heart Study.

ABSTRACT:

Background

Elevated blood pressure is the leading modifiable risk factor for cardiovascular disease (CVD) and premature death. The blood pressure waveform consists of discrete hemodynamic components, derived from measured central pressure and flow, which may contribute separately to risk for an adverse outcome. However, pressure-flow measures have not been studied in a large, community-based sample.

Methods and results

We used proportional hazards models to examine the association of incident CVD with forward pressure wave amplitude, mean arterial pressure, and global reflection coefficient derived from wave separation analysis and echocardiography in 2492 participants (mean age 66±9 years, 56% women) in the Framingham Heart Study. During follow-up (0.04-6.8 years), 149 part

SUBMITTER: Cooper LL 

PROVIDER: S-EPMC4308473 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature