Traffic pollution is associated with early childhood aeroallergen sensitization.

ABSTRACT:

Background

No large, prospective, epidemiologic study has investigated the association between diesel exhaust particle (DEP) exposure and early aeroallergen sensitization and allergic rhinitis (AR) at 4 years of age.

Objective

To determine how exposure to traffic exhaust during infancy is associated with aeroallergen sensitization and AR at 4 years of age and the predictive utility of the wheal area at 1 to 3 years of age on AR at 4 years of age.

Methods

Infants born to aeroallergen sensitized parents were evaluated annually with skin prick tests to 15 aeroallergens with measurement of wheal areas. At 4 years of age, AR was defined as at least one positive aeroallergen skin prick test result and the presence of sneezing and a runny nose without a cold or flu. Infant (

SUBMITTER: Codispoti CD 

PROVIDER: S-EPMC4308502 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature