Measures of obesity and risk of Crohn's disease and ulcerative colitis.

ABSTRACT:

Background

Obesity is associated with intestinal-specific inflammation. Nonetheless, a specific role of obesity in the etiology of inflammatory bowel disease is unclear.

Methods

We conducted a prospective cohort study of U.S. women enrolled in 1989 in the Nurses' Health Study II. At baseline, we collected information on height, weight, waist and hip circumference, weight at age 18, and body shape at age 20. We used Cox proportional hazard models to calculate hazard ratios and 95% confidence intervals (CIs).

Results

Among 111,498 women (median age, 35 yr), we documented 153 cases of Crohn's disease (CD) and 229 cases of ulcerative colitis (UC) more than 18 years of follow-up, encompassing 2,028,769 person-years. Compared with women with normal BMI, the multivariate-adj

SUBMITTER: Khalili H 

PROVIDER: S-EPMC4308549 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature