Enhanced transcriptome maps from multiple mouse tissues reveal evolutionary constraint in gene expression.

ABSTRACT: Mice have been a long-standing model for human biology and disease. Here we characterize, by RNA sequencing, the transcriptional profiles of a large and heterogeneous collection of mouse tissues, augmenting the mouse transcriptome with thousands of novel transcript candidates. Comparison with transcriptome profiles in human cell lines reveals substantial conservation of transcriptional programmes, and uncovers a distinct class of genes with levels of expression that have been constrained early in vertebrate evolution. This core set of genes captures a substantial fraction of the transcriptional output of mammalian cells, and participates in basic functional and structural housekeeping processes common to all cell types. Perturbation of these constrained genes is associated with significant

SUBMITTER: Pervouchine DD 

PROVIDER: S-EPMC4308717 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature