Bone marrow stromal antigen 2 expressed in cancer cells promotes mammary tumor growth and metastasis.

ABSTRACT:

Introduction

Several innate immunity genes are overexpressed in human cancers and their roles remain controversial. Bone marrow stromal antigen 2 (BST-2) is one such gene whose role in cancer is not clear. BST-2 is a unique innate immunity gene with both antiviral and pro-tumor functions and therefore can serve as a paradigm for understanding the roles of other innate immunity genes in cancers.

Methods

Meta-analysis of tumors from breast cancer patients obtained from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets were evaluated for levels of BST-2 expression and for tumor aggressiveness. In vivo, we examined the effect of knockdown of BST-2 in two different murine carcinoma cells on tumor growth, metastasis, and survival. In vitro, we assessed

SUBMITTER: Mahauad-Fernandez WD 

PROVIDER: S-EPMC4308845 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature