Higher gene expression variability in the more aggressive subtype of chronic lymphocytic leukemia.

ABSTRACT:

Background

Chronic lymphocytic leukemia (CLL) presents two subtypes which have drastically different clinical outcomes, IgVH mutated (M-CLL) and IgVH unmutated (U-CLL). So far, these two subtypes are not associated to clear differences in gene expression profiles. Interestingly, recent results have highlighted important roles for heterogeneity, both at the genetic and at the epigenetic level in CLL progression.

Methods

We analyzed gene expression data of two large cohorts of CLL patients and quantified expression variability across individuals to investigate differences between the two subtypes using different measures and statistical tests. Functional significance was explored by pathway enrichment and network analyses. Furthermore, we implemented a random forest approach b

SUBMITTER: Ecker S 

PROVIDER: S-EPMC4308895 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature