Admixture analysis of spontaneous hepatitis C virus clearance in individuals of African descent.

ABSTRACT: Hepatitis C virus (HCV) infects an estimated 3% of the global population with the majority of individuals (75-85%) failing to clear the virus without treatment, leading to chronic liver disease. Individuals of African descent have lower rates of clearance compared with individuals of European descent and this is not fully explained by social and environmental factors. This suggests that differences in genetic background may contribute to this difference in clinical outcome following HCV infection. Using 473 individuals and 792,721 single-nucleotide polymorphisms (SNPs) from a genome-wide association study (GWAS), we estimated local African ancestry across the genome. Using admixture mapping and logistic regression, we identified two regions of interest associated with spontaneous clearance

SUBMITTER: Wojcik GL 

PROVIDER: S-EPMC4308959 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature