Ventrolateral and dorsomedial frontal cortex lesions impair mnemonic context retrieval.

ABSTRACT: The prefrontal cortex appears to contribute to the mnemonic retrieval of the context within which stimuli are experienced, but only under certain conditions that remain to be clarified. Patients with lesions to the frontal cortex, the temporal lobe and neurologically intact individuals were tested for context memory retrieval when verbal stimuli (words) had been experienced across multiple (unstable context condition) or unique (stable context condition) contexts; basic recognition memory of these words-in-contexts was also tested. Patients with lesions to the right ventrolateral prefrontal cortex (VLPFC) were impaired on context retrieval only when the words had been seen in multiple contexts, demonstrating that this prefrontal region is critical for active retrieval processing necessary

SUBMITTER: Chapados C 

PROVIDER: S-EPMC4309002 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature