Functional analysis of the TRIB1 associated locus linked to plasma triglycerides and coronary artery disease.

ABSTRACT:

Background

The TRIB1 locus has been linked to hepatic triglyceride metabolism in mice and to plasma triglycerides and coronary artery disease in humans. The lipid-associated single nucleotide polymorphisms (SNPs), identified by genome-wide association studies, are located ≈30 kb downstream from TRIB1, suggesting complex regulatory effects on genes or pathways relevant to hepatic triglyceride metabolism. The goal of this study was to investigate the functional relationship between common SNPs at the TRIB1 locus and plasma lipid traits.

Methods and results

Characterization of the risk locus reveals that it encompasses a gene, TRIB1-associated locus (TRIBAL), composed of a well-conserved promoter region and an alternatively spliced transcript. Bioinformatic analysis and reseque

SUBMITTER: Douvris A 

PROVIDER: S-EPMC4309087 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature