Power law relationship between cell cycle duration and cell volume in the early embryonic development of Caenorhabditis elegans.

ABSTRACT: Cell size is a critical factor for cell cycle regulation. In Xenopus embryos after midblastula transition (MBT), the cell cycle duration elongates in a power law relationship with the cell radius squared. This correlation has been explained by the model that cell surface area is a candidate to determine cell cycle duration. However, it remains unknown whether this second power law is conserved in other animal embryos. Here, we found that the relationship between cell cycle duration and cell size in Caenorhabditis elegans embryos exhibited a power law distribution. Interestingly, the powers of the time-size relationship could be grouped into at least three classes: highly size-correlated, moderately size-correlated, and potentially a size-non-correlated class according to C. elegans founder

SUBMITTER: Arata Y 

PROVIDER: S-EPMC4309120 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature