Preoperative low-dose ketamine has no preemptive analgesic effect in opioid-naive patients undergoing colon surgery when nitrous oxide is used - a randomized study.

ABSTRACT:

Background

The analgesic properties of ketamine are associated with its non-competitive antagonism of the N-methyl-D-aspartate receptor; these receptors exhibit an excitatory function on pain transmission and this binding seems to inhibit or reverse the central sensitization of pain. In the literature, the value of this anesthetic for preemptive analgesia in the control of postoperative pain is uncertain. The objective of this study was to ascertain whether preoperative low-dose ketamine reduces postoperative pain and morphine consumption in adults undergoing colon surgery.

Methods

In a double-blind, randomized trial, 48 patients were studied. Patients in the ketamine group received 0.5 mg/kg intravenous ketamine before surgical incision, while the control group received nor

SUBMITTER: Nistal-Nuno B 

PROVIDER: S-EPMC4309164 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature