Minocycline treatment ameliorates interferon-alpha- induced neurogenic defects and depression-like behaviors in mice.

ABSTRACT: Interferon-alpha (IFN-α) is a proinflammatory cytokine that is widely used for the treatment of chronic viral hepatitis and malignancy, because of its immune-activating, antiviral, and antiproliferative properties. However, long-term IFN-α treatment frequently causes depression, which limits its clinical utility. The precise molecular and cellular mechanisms of IFN-α-induced depression are not currently understood. Neural stem cells (NSCs) in the hippocampus continuously generate new neurons, and some evidence suggests that decreased neurogenesis plays a role in the neuropathology of depression. We previously reported that IFN-α treatment suppressed hippocampal neurogenesis and induced depression-like behaviors via its receptors in the brain in adult mice. However, it is unclear how system

SUBMITTER: Zheng LS 

PROVIDER: S-EPMC4309184 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature