Extension of Drosophila lifespan by cinnamon through a sex-specific dependence on the insulin receptor substrate chico.

ABSTRACT: Cinnamon is a spice commonly used worldwide to flavor desserts, fruits, cereals, breads, and meats. Numerous health benefits have been attributed to its consumption, including the recent suggestion that it may decrease blood glucose levels in people with diabetes. Insulin signaling is an integral pathway regulating the lifespan of laboratory organisms, such as worms, flies, and mice. We posited that if cinnamon truly improved the clinical signs of diabetes in people that it would also act on insulin signaling in laboratory organisms and increase lifespan. We found that cinnamon did extend lifespan in the fruit fly, Drosophila melanogaster. However, it had no effect on the expression levels of the 3 aging-related Drosophila insulin-like peptides nor did it alter sugar, fat, or soluble prote

SUBMITTER: Schriner SE 

PROVIDER: S-EPMC4309393 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature