Cortical activity evoked by inoculation needle prick in infants up to one-year old.

ABSTRACT: Inoculation is one of the first and most common experiences of procedural pain in infancy. However, little is known about how needle puncture pain is processed by the central nervous system in children. In this study, we describe for the first time the event-related activity in the infant brain during routine inoculation using electroencephalography. Fifteen healthy term-born infants aged 1 to 2 months (n = 12) or 12 months (n = 5) were studied in an outpatient clinic. Pain behavior was scored using the Modified Behavioral Pain Scale. A distinct inoculation event-related vertex potential, consisting of 2 late negative-positive complexes, was observable in single trials after needle contact with the skin. The amplitude of both negative-positive components was significantly greater in the 12

SUBMITTER: Verriotis M 

PROVIDER: S-EPMC4309489 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature