Polarised clathrin-mediated endocytosis of EGFR during chemotactic invasion.

ABSTRACT: Directed cell migration is critical for numerous physiological processes including development and wound healing. However chemotaxis is also exploited during cancer progression. Recent reports have suggested links between vesicle trafficking pathways and directed cell migration. Very little is known about the potential roles of endocytosis pathways during metastasis. Therefore we performed a series of studies employing a previously characterised model for chemotactic invasion of cancer cells to assess specific hypotheses potentially linking endocytosis to directed cell migration. Our results demonstrate that clathrin-mediated endocytosis is indispensable for epidermal growth factor (EGF) directed chemotactic invasion of MDA-MB-231 cells. Conversely, caveolar endocytosis is not required in

SUBMITTER: Mutch LJ 

PROVIDER: S-EPMC4309520 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature