Strategies of eradicating glioma cells: a multi-scale mathematical model with MiR-451-AMPK-mTOR control.

ABSTRACT: The cellular dispersion and therapeutic control of glioblastoma, the most aggressive type of primary brain cancer, depends critically on the migration patterns after surgery and intracellular responses of the individual cancer cells in response to external biochemical and biomechanical cues in the microenvironment. Recent studies have shown that a particular microRNA, miR-451, regulates downstream molecules including AMPK and mTOR to determine the balance between rapid proliferation and invasion in response to metabolic stress in the harsh tumor microenvironment. Surgical removal of main tumor is inevitably followed by recurrence of the tumor due to inaccessibility of dispersed tumor cells in normal brain tissue. In order to address this multi-scale nature of glioblastoma proliferation and

SUBMITTER: Kim Y 

PROVIDER: S-EPMC4309536 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature