Ligand-dependent opening of the multiple AMPA receptor conductance states: a concerted model.

ABSTRACT: Modulation of the properties of AMPA receptors at the post-synaptic membrane is one of the main suggested mechanisms underlying fast synaptic transmission in the central nervous system of vertebrates. Electrophysiological recordings of single channels stimulated with agonists showed that both recombinant and native AMPA receptors visit multiple conductance states in an agonist concentration dependent manner. We propose an allosteric model of the multiple conductance states based on concerted conformational transitions of the four subunits, as an iris diaphragm. Our model predicts that the thermodynamic behaviour of the conductance states upon full and partial agonist stimulations can be described with increased affinity of receptors as they progress to higher conductance states. The model

SUBMITTER: Dutta-Roy R 

PROVIDER: S-EPMC4309570 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature